What dietary and lifestyle habits should you pay attention to while taking Tepotinib?

During treatment with Tepotinib (Tepotinib), in addition to taking the medication as prescribed by the doctor, patients also need to pay attention to their diet and lifestyle habits to improve the efficacy of the drug and reduce adverse reactions. The following are four points to note while taking tepotinib for the reference of patients and their families:

1. Eat regularly and avoid fatty and greasy foods

Tepotinib is an oral MET inhibitor. Its absorption has little to do with food. However, it is still recommended to take it with food at a fixed time every day to facilitate gastrointestinal tolerance. Patients should try to avoid high-fat, spicy, greasy and irritating foods during medication. Such diets may aggravate adverse reactions such as nausea and diarrhea. It is recommended to consume more foods that are light, easy to digest, and rich in protein and vitamins, such as white rice porridge, lean meat, soy products, green leafy vegetables, etc., which can help enhance physical strength and immunity.

2. Limit foods and drinks containing pomelo ingredients

Avoid eating grapefruit or drinking grapefruit juice while taking tepotinib. This is because the furanocoumarins contained in grapefruit may inhibit the activity of CYP3A4 enzyme in the liver, which is involved in the metabolism of tepotinib. If CYP3A4 is inhibited, it may lead to an increase in drug concentration in the blood, thereby aggravating side effects, such as abnormal liver function, edema, fatigue, etc. Therefore, be sure to avoid all foods containing pomelo during medication.

3. Stay hydrated and maintain a regular schedule

Some patients may experience poor appetite, fatigue, weight changes, etc. during medication. Maintaining adequate water intake is particularly important for body metabolism and reducing side effects. The recommended daily water intake is around 1500-2000ml, especially when mild diarrhea, dry mouth or constipation occurs. In addition, regular work and rest can help maintain immune function and drug metabolism. It is recommended to avoid staying up late, ensure adequate sleep time, and control stress, which can help enhance the efficacy of drugs.

4. Avoid taking other drugs or health products by yourself

During the use of Tepotinib, patients are not recommended to use other drugs, herbal supplements or health products without authorization, especially ingredients that may affect liver and kidney function or are metabolized by CYP enzymes, to avoid drug interactions or affecting Tepotinib plasma concentration. If combined medication is needed, the doctor should be informed in advance of all the medicines being used, including traditional Chinese medicine and vitamin supplements, and the doctor will decide whether they can be used together after evaluation. In addition, regular follow-up and testing of liver function, electrolyte levels and lung CT results are also important aspects that cannot be ignored during medication.

In short, by paying attention to the dietary structure, avoiding specific foods, ensuring regular life, and avoiding inappropriate medication during Tepotinib treatment, it can improve the safety of treatment while enhancing the efficacy and bringing a better treatment experience to patients.

Reference materials:https://www.tepotinib.com/