What is the price of generic Besudil mesylate tablets?

Belumosudil mesylate tablets (Belumosudil) is an oral small molecule drug that targets ROCK2 (Rho-associated coiled-coil-forming protein kinase 2). Its main mechanism of action is to inhibit this signaling pathway, thereby regulating immune cell function, inhibiting inflammatory responses and slowing down the fibrosis process. This makes besudil unique in the treatment of chronic graft-versus-host disease (cGVHD), especially for patients who are ineffective or relapsed with traditional treatments. The US FDA has approved it for the treatment of patients with cGVHD that cannot be relieved after receiving more than two systemic treatment regimens, covering adults and children aged 12 years and above.

Regarding the price of the drug, since the pricing system of the original drug is mainly affected by the research and development costs, market monopoly period and the medical insurance policy of the country where it is listed, the market price of Besudil in the United States and other countries is relatively high, and in some countries the price even exceeds tens of thousands of dollars per year. This high cost of treatment places a greater financial burden on some patients and the medical system, so the emergence of generic drugs has significant clinical and economic significance.

In recent years, with the gradual expiration of patent protection, some overseas pharmaceutical companies have begun to develop and market generic versions of Besudil. Among them, the Laos Luscius Pharmaceutical Factory is the representative. The generic specifications produced by it are basically the same as the original drug in terms of ingredients, dosage and dosage, and have similar bioavailability and efficacy. According to market information, the price of this generic drug in Southeast Asia and some regions is significantly lower than that of the original product. The price per box of some specifications is about 4,000 yuan. The specific price may be adjusted due to exchange rate fluctuations and differences in import channels.

Reference: https://www.drugs.com/pro/rezurock.html