How to monitor blood routine and liver and kidney function during gosatuzumab/Todavir treatment

Gosatuzumab/Trodelvy (Trodelvy) is a drug for the treatment of metastatic breast cancer. Possible toxic reactions during its treatment, especially the impact on the blood system and liver and kidney function, require continuous monitoring. Monitoring of blood routine, liver function and renal function not only helps to detect adverse reactions in time, but also provides a basis for adjustment of clinical treatment. Before treatment, doctors usually ask patients to conduct a baseline blood routine examination to assess the basic status of white blood cells, red blood cells, platelets, and neutrophils. In addition, liver function tests (including ALT, AST, bilirubin, etc.) and renal function (creatinine, urea nitrogen) assessment are also standard examination items. These examinations can provide a reference for risk prediction and management during treatment.

During gosatuzumab treatment, liver function needs to be checked regularly, especially during the first few weeks of treatment, as the drug is metabolized by the liver and may have effects on liver function. If liver function abnormalities are found, dose adjustment or treatment delay should be considered. In addition, if symptoms such as persistent nausea, vomiting, and loss of appetite occur during treatment, it may indicate that the liver is affected, and liver function tests must be used to confirm and appropriate intervention measures must be taken.

Regarding monitoring of renal function, although gosatuzumab is mainly metabolized by the liver, patients with renal insufficiency still require special attention. During treatment, patients should regularly detect creatinine and urea nitrogen to assess whether renal function has changed. If a decrease in kidney function is found, the drug regimen may need to be adjusted or the drug dosage may need to be reduced. In addition, myelosuppression is also a common side effect of gosatuzumab treatment, so regular monitoring of blood routine, especially neutrophil and platelet counts, is crucial.

Reference materials:https://www.trodelvy.com/