What drug interactions should you pay attention to when combining gosatuzumab/tudavir with chemotherapy drugs?

Gosatuzumab/Trodelvy (Trodelvy), as an antibody drug conjugate (ADC), is mainly used to treat advanced or metastatic triple-negative breast cancer and other cancers. In some cases, gosatuzumab is clinically chosen to be used in combination with other chemotherapy drugs to improve treatment efficacy or overcome drug resistance. However, during drug combination, some drug interactions may occur, affecting the safety and effectiveness of treatment. The active ingredient of gosatuzumab is an irinotecan derivativeThe metabolic pathway of SN-38 depends on the UGT1A1 enzyme in the liver, which means that any drug that interferes with the activity of this enzyme will affect the metabolic process of SN-38.

Therefore, if combined with drugs that affectUGT1A1 enzyme activity, such as some antibiotics (such as cephalosporins), antiviral drugs or anti-epileptic drugs, the toxic reactions of gosatuzumab may be aggravated and lead to increased hematological toxicity, such as neutropenia, etc. In addition, when used in combination with drugs that have bone marrow suppression (such as platinum drugs, paclitaxel, etc.), it may aggravate bone marrow suppression, leading to a decrease in white blood cell count, platelet count, etc., and an increased risk of bleeding and infection. Therefore, it is necessary to strengthen routine blood monitoring of patients.

The combined use of drugs may also increase the incidence of gastrointestinal adverse reactions. Gosatuzumab itself has strong gastrointestinal toxicity, and when combined with other chemotherapy drugs (such as fluorouracil drugs or taxane drugs), it may aggravate the patient's nausea, vomiting, diarrhea and other symptoms. In order to avoid these adverse reactions, doctors need to carefully evaluate drug interactions when formulating treatment plans and try to avoid combined use with drugs that have greater interactions. In addition, when patients take gosatuzumab, they should avoid taking some drugs that may affect liver and kidney function, because the liver and kidneys are the key organs for the metabolism and elimination of this drug.

Reference materials:https://www.trodelvy.com/