What are the side effects of Imaavy (nipocalimab-aahu)?

Imaavy (nipocalimab-aahu) is a novel treatment for generalized myasthenia gravis (gMG), specifically for patients 12 years and older who are positive for anti-acetylcholine receptor (AChR) or anti-muscle-specific tyrosine kinase (MuSK) antibodies. In clinical application, Imaavy has shown certain efficacy, but it is also accompanied by some side effects, which require the joint attention and management of doctors and patients.

First of all, respiratory infection is one of the most common adverse reactions during the use of Imaavy, with an incidence rate of more than 10%. While receiving treatment, patients may develop symptoms of upper respiratory tract infections, such as cough, sore throat, and flu-like illness. The occurrence of such infections is related to Imaavy's impact on the immune system. Therefore, doctors need to evaluate the patient's infection history before treatment and maintain close monitoring during treatment.

Secondly, peripheral edema is also a noteworthy side effect, and patients may experience swelling in their limbs or other parts. This edema may affect the patient's quality of life, causing limited mobility or discomfort. Therefore, in clinical practice, patients' edema should be regularly assessed and adjustments made as needed.

Muscle spasms are also one of the common reactions that patients may experience while usingImaavy. This symptom may be related to the patient's original myasthenic pathology, or it may be a side effect of the drug itself. For patients experiencing muscle spasms, appropriate support and treatment should be provided to relieve symptoms.

Infections, allergic reactions, and infusion-related reactions are listed as important warnings and precautions during the use of Imaavy. Because Imaavy may increase the risk of infection, treatment should not be started immediately in patients with active infection. In addition, the potential risk of allergic reactions cannot be ignored. Patients have experienced angioedema or other hypersensitivity reactions after using Imaavy. Therefore, patients with a history of severe allergy to any drug or ingredient should avoid using this drug for their own safety.

Reference materials:https://www.drugs.com/imaavy.html#side-effects