Are there any generic versions of daprexostat currently being produced and sold?

Daprodustat (Daprodustat) is a new type of hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), mainly used to treat anemia related to chronic kidney disease (CKD). Due to kidney damage in patients with chronic kidney disease, the synthesis of endogenous erythropoietin (EPO) is reduced, and patients are often accompanied by moderate to severe anemia. Daprostat inhibits prolyl hydroxylase, activates the hypoxia-inducible factor pathway, promotes the body's own EPO secretion, thereby stimulating bone marrow red blood cell production and improving anemia symptoms. In addition, dapoxostat can also regulate iron metabolism in the body, reduce serum hepcidin levels, improve iron utilization efficiency, and work together from multiple links to significantly improve anemia.

Currently, daprostat has been approved overseas for the treatment of anemia in patients with chronic kidney disease who are receiving dialysis or not receiving dialysis. It is especially suitable for patients who want to avoid frequent injections of erythropoietin. According to public information, the common dosage forms of daprostat are 1mg, 2mg, 4mg, 6mg, 8mg and other specifications. They are administered orally, which greatly improves the convenience of medication for patients.

Regarding the issue of price and generic drugs, the original drug of daprostat has not yet been launched in the domestic market and has not been included in the medical insurance catalog, so its price in mainland China is not yet clear. However, in the United States, Japan and other places, the original drug is already available in common specifications such as 1 mg 30 tablets and 2 mg 30 tablets. The price per box is roughly between one hundred and five hundred US dollars. The specific price will vary slightly with exchange rate fluctuations.

It is worth noting that the first generic version of daprostat has appeared overseas. Among them, the generic version of daprostat launched by Lucius Pharmaceuticals in Laos has been circulated in some markets. For example, the specification is 1mg*100 tablets, and each box may be sold for more than 400 yuan. Generic drugs are basically the same as the original drugs in terms of drug ingredients and clinical effects, providing patients with more economical and affordable treatment options.

Although the launch of generic drugs has brought price advantages to patients, since there is no approved version in China, patients need to carefully evaluate the source formality and drug safety when choosing, and they can use them rationally under the guidance of a doctor.

Reference: https://en.wikipedia.org/wiki/Daprodustat