Who is the manufacturer of Penpulimab?

Penpulimab (Penpulimab) is an innovative humanized anti-PD-1 monoclonal antibody drug jointly developed by Akeso Biopharma and Zhengda Tianqing (a subsidiary of Sino Biopharmaceutical). Kangfang Biologics is a China-based biopharmaceutical company focused on the research and development of innovative drugs in the field of tumor immunotherapy and autoimmune diseases, while Chia Tai Tianqing is one of China's leading anti-tumor drug manufacturers with strong clinical development and commercialization capabilities. This cooperation combines Kangfang's advantages in biotechnology innovation and Chia Tai Tianqing's deep accumulation in clinical development, production and marketing, providing a solid guarantee for the rapid advancement and application of amprilimab.

Panpilimab is an immunoglobulinG1 (IgG1) subtype monoclonal antibody, but unlike traditional IgG1 antibodies, it is designed through molecular engineering to completely eliminate the binding to Fcγ receptors and Fc-mediated effector functions, thus reducing the risk of inducing unnecessary immune responses and enhancing the safety of medication. As a new generation of PD-1 inhibitors, penpilimab is mainly used to treat a variety of malignant tumors, including relapsed or refractory classical Hodgkin lymphoma (cHL), nasopharyngeal carcinoma, non-small cell lung cancer and other solid tumors. In August 2021, penpilimabwas officially approved by the National Medical Products Administration (NMPA) in China for the treatment of adult patients with relapsed or refractory classic Hodgkin lymphoma who have received at least two lines of systemic therapy or more. This is the first time it has been launched in the world.

Currently, penpilimab is also undergoing multiple clinical trials in China and Australia, covering the treatment of nasopharyngeal cancer, non-small cell lung cancer and other solid tumors, and some indications are also in the process of regulatory review.

Reference materials:https://pubmed.ncbi.nlm.nih.gov/34813051/