Where can I buy the genuine version of Enxidipine? Regular channel buying guide!

Enasidenib is an oral targeted therapy drug, mainly suitable for the treatment of relapsed or refractory acute myeloid leukemia (AML) adult patients with isocitrate dehydrogenase 2 (IDH2) gene mutations. It selectively inhibits the mutated IDH2 enzyme and reduces the production of the abnormal metabolite 2-hydroxyglutarate (2-HG), thereby promoting the recovery of the maturation process of leukemia cells with abnormal differentiation and stasis, achieving the purpose of treatment. Ensidipine received accelerated approval from the US FDA in 2017 and became one of the first precision treatments for IDH2-mutated AML. It is especially suitable for elderly patients who are ineffective or poorly tolerated by traditional chemotherapy. In clinical studies, it has shown a good response rate and durable survival benefit.

Currently, ensidipine is not available on the market in China, so it cannot be reimbursed through national medical insurance channels. This means that if patients need medicine, they need to purchase it through formal overseas channels. According to existing market information, the common specifications of overseas original research version of Encidipine are 50mg and 100mg, with 30 tablets per box, and the price may be as high as RMB 300,000. The specific price changes with exchange rate fluctuations. Since the high cost of original drugs poses a certain burden to patients, some overseas countries and regions have launched generic versions. For example, generic drugs produced by pharmaceutical companies in Laos and other countries have a specification of 50mg*30 tablets and a price of about RMB 1,000 per box. Although the price is significantly lower than that of the original drug, the active ingredients and bioavailability of generic drugs are usually highly consistent with the original drug, and the clinical effects are close to that of the original drug. They have become the choice of many patients with limited economic conditions.

For domestic patients, if they need to use ensidipine, they should first confirm with a doctor whether they carry the IDH2 mutant gene. This can be confirmed through genetic testing, and then choose reliable overseas drug purchase channels under the guidance of professional institutions to avoid the risk of counterfeit and substandard drugs due to unknown channels.

Reference materials:https://www.idhifa.com/