What is the dosage and administration of enzalutamide? How to take it correctly according to doctor's advice?

Enzalutamide is an androgen receptor inhibitor mainly used to treat castration-resistant prostate cancer (CRPC) or metastatic castration-sensitive prostate cancer (mCSPC). The recommended dose is 160 mg once daily, which is four 40 mg capsules or tablets. Patients can choose to take it before or after meals, but they should try to take it at the same time every day to maintain a stable blood concentration of the drug and improve the therapeutic effect.

When taking enzalutamide, the tablet should be swallowed whole and avoid crushing, chewing or breaking to avoid affecting the release characteristics and absorption efficiency of the drug. If the patient needs to adjust the dosage due to difficulty swallowing, this must be done under the guidance of a doctor. In addition, patients are not allowed to increase or decrease the dose or stop the medication without authorization, so as not to affect the treatment effect or lead to disease progression. If you miss a dose, you should take it as soon as possible on the same day, but if it is close to the next dose time, you should skip the missed dose to avoid overdose in a short period of time.

During treatment, the doctor may adjust the dosage or take management measures based on the patient's individual condition. For example, doctors may reduce the dose or suspend treatment if a patient experiences serious adverse reactions, such as fatigue, dizziness, high blood pressure, seizures, or other neurological symptoms. Therefore, patients should review regularly, monitor liver function, blood pressure and other important physiological indicators, and promptly report any discomfort to the doctor so that corresponding adjustments can be made.

In addition, enzalutamide may interact with other drugs, especially anticoagulants, certain antiepileptic drugs, and drugs that are substrates of CYP3A4 and CYP2C8 enzymes. Therefore, before starting treatment, patients should proactively inform their doctors about all the medications they are taking to avoid potential adverse reactions. At the same time, you should try to avoid drinking alcohol while taking the medication, and be cautious in high-risk activities such as driving or operating machinery to reduce the impact of neurological side effects.

Reference materials:https://www.xtandi.com/