What are the side effects of Glasdegib?

Glasdegib is a targeted drug used to treat acute myeloid leukemia (AML) and has attracted attention in clinical applications in recent years. Although it is effective in treating diseases, many side effects may occur during use. According to clinical research data, the most common adverse reactions of Glasgib include anemia, fatigue and bleeding. These side effects are often related to the drug's suppressive effect on the bone marrow, resulting in a decrease in blood components, which in turn causes fatigue and bleeding tendencies in the patient.

In addition, granulocytopenia is also one of the side effects that requires special attention when using Glasgib. Granulocytopenia refers to a decrease in the number of granulocytes in white blood cells, which makes patients susceptible to infection and may manifest as fever and other symptoms of infection. Musculoskeletal pain is also a common reaction and may affect patients' daily activities and quality of life. Digestive system discomforts such as nausea, edema and constipation may make patients feel uncomfortable during treatment and affect their appetite and nutritional intake.

Thrombocytopenia is also an important side effect when using Glasgib, which may lead to an increased risk of bleeding and requires regular monitoring of blood routine indicators. In addition, symptoms such as dyspnea and dysgeusia also need to be taken seriously, as these reactions may affect the patient's overall health and life experience. Skin reactions such as mucositis and rashes need to be treated promptly to reduce patient discomfort.

Glasgib may also pose a risk of embryo-fetotoxicity and QTc interval prolongation when combined with low-dose cytarabine treatment. Such reactions require strict monitoring, especially in female patients and pregnant women. Prolongation of the QTc interval may lead to serious cardiac complications that require ECG monitoring to prevent.

Reference materials:https://www.ema.europa.eu/en/medicines/human/EPAR/daurismo