Which generation of targeted drug is sotorasib? The development history of targeted therapy

Sotorasib (AMG510, Sotorasib) is a targeted therapy specifically targeting cancers with KRAS G12C mutations, specifically non-small cell lung cancer (NSCLC). Unlike traditional targeted drugs, sotorasiib represents a major breakthrough in the treatment of KRAS mutant cancers. This type of cancer was once considered difficult to treat because KRAS gene mutations often show drug resistance in cancer. Sotoraxib can specifically inhibit the KRAS G12C mutation, marking an important progress in the field of targeted tumor therapy.

Sotoracib does not belong to the first or second generation of targeted drugs in the traditional sense, but can be regarded as a "new generation of targeted drugs". It is the first FDA-approved drug among the KRAS inhibitors, specifically targeted at cancer patients who carry the KRAS G12C mutation. Therefore, the targeting effect of sotoraxib is different from common targeted drugs, such as targeted drugs targeting EGFR inhibitors, HER2 and other receptors. It effectively blocks the growth signals of tumor cells by irreversibly binding and inhibiting the KRAS G12C mutant protein, thereby inhibiting the spread of cancer cells.

As a new type of targeted drug, the mechanism of action of sotoraxib is different from traditional targeted drugs, marking a new era in the treatment of KRAS mutant cancers KRAS mutations have a high incidence in many types of cancer, especially in non-small cell lung cancer, colorectal cancer, etc. In the past, due to the complex structure of the KRAS protein, it has been difficult to develop drugs targeting its mutations. Therefore, the launch of sotorasiib is a milestone.

Compared with previous generations of targeted drugs, sotoraxib represents a more precise molecular targeted therapy, especially in the personalized treatment of cancer, which has great potential. By precisely targeting the KRAS G12C mutation, sotoraxib can prolong the survival of patients and improve treatment effects to a certain extent.

Reference materials:https://www.lumakras.com/