What are the side effects of intravenous human immunoglobulin (Yimmugo)?

Intravenous human immunoglobulin (Yimmugo) is a drug used to treat primary humoral immunodeficiency, and its side effects require the attention of clinical users. During the process of intravenous injection, patients may experience a variety of side effects, and the occurrence of these side effects is closely related to factors such as individual physique, immune status, and injection speed.

In clinical observations, the most common adverse reactions include headache, upper respiratory tract infection, fatigue, nausea and increased blood pressure. These reactions are usually mild and resolve spontaneously in most patients after stopping the injection. However, some patients may experience more serious side effects, such as allergic reactions. Anaphylaxis may manifest as rash, itching or even more severe anaphylactic shock, so patients need to be carefully questioned about their past allergies before injections.

In addition, intravenous injection of human immune globulin may also cause hemolysis, especially in patients with a history of previous blood transfusions. This situation usually requires monitoring the patient's blood picture changes and taking appropriate measures based on the severity. Thrombosis is also one of the side effects that needs attention, especially in patients who are bedridden for a long time or have a history of thrombosis. After injection, you should pay attention to symptoms such as swelling and pain in the lower limbs.

In addition, side effects such as renal failure, hyperalbuminemia, and increased serum viscosity have also been reported in clinical studies. In particular, an increase in serum viscosity may cause microcirculation disorders, thereby affecting tissue oxygen supply. Therefore, when administering intravenous injections, the patient's basic renal function should be assessed and renal function monitored if necessary.

Aseptic meningitis syndrome and transfusion-related acute lung injury are rare but dangerous side effects that usually require immediate attention and may require discontinuation of the drug. Regarding the risk of infectious pathogens, although modern immunoglobulin preparations are rigorously screened, patients still need to be reminded of the possible risk of microbial infection.

Reference materials:https://en.wikipedia.org/wiki/Main_Page