How Bedaquiline works

Bedaquiline tablets (Bedaquiline) is an anti-tuberculosis drug. Its mechanism of action mainly involves the ATP synthase (ATP) during the cell wall synthesis of Mycobacterium tuberculosis (Mycobacterium tuberculosis) synthase).

The role of ATPsynthase:ATPsynthase is an enzyme complex located on the bacterial cell membrane. It plays a key role in cellular metabolism. It can use the intracellular proton gradient to convert inorganic phosphate compounds (ADP) into adenosine triphosphate (ATP), providing the energy needed by bacteria.

The role of bedaquiline: Bedaquiline is an ATP synthase inhibitor that interferes with the function of the enzyme complex by binding to the c subunit of ATP synthase (subunit c). This binding blocks the flow of protons, thereby destroying the activity of ATP synthase, preventing the bacteria from efficiently producing energy.

Inhibition of bacterial growth: Due to the effect of bedaquiline onATP synthase, the energy supply of bacteria is interrupted, resulting in the inhibition of bacterial growth and replication processes. This allows bedaquiline to inhibit the proliferation and spread of Mycobacterium tuberculosis.

Bedaquiline tablets have been launched in China and have been included in Class B medical insurance. Patients can buy it domestically, but the price is very high. The price of 100mg*24tablets is around 15,000 yuan. For specific prices, please consult the local hospital pharmacy. There are only original drugs abroad, and the more cost-effective ones are Russian original drugs. The price of 100mg*188 tablets is also about 15,000 yuan. The specifications are about 8 times that of domestic ones. Relatively speaking, the price is still very cheap compared to domestic ones. And the ingredients of domestic and foreign original drugs are consistent.