Are there generic versions of tepotinib?

Tepotinib (tepotinib), as a tyrosine kinase inhibitor (TKI), has the ability to highly selectively inhibit the activity of MET receptor kinase. It blocks the kinase activity required for normal MET signaling by binding to the MET receptor and competitively occupying the ATP binding site. This can reduce the activity of the MET signaling pathway and inhibit the growth, proliferation and migration capabilities of cancer cells.

Non-small cell lung cancer (NSCLC) is still the most common malignant tumor among lung cancers, and its mortality rate has been increasing in recent years. NSCLC accounts for more than 80% of lung cancers, and the vast majority of patients are found in advanced inoperable stages. Tepotinib, a highly selective MET inhibitor, inhibits MET overexpression and MET amplification. In a phase II study of 152 patients treated, the objective response rate was 46% in the liquid biopsy group and 50% in the biopsy group.

The original drug Tepotinib is a new type of drug that has not yet been marketed in China, so it has not been included in the medical insurance. Domestic patients cannot yet purchase this drug in pharmacies or hospitals. The price of Tepotinib's original drug specification 225mg*30 tablets per box is around RMB 80,000 per box (the price may fluctuate due to exchange rate effects). It has been on the market for a short time and is expensive. There are also generic Tepotinib drugs produced in other countries. The price of a box of 225mg*60 tablets produced by a Lao pharmaceutical factory is around RMB 8,600 (the price may fluctuate due to the exchange rate). The ingredients of generic drugs produced abroad are basically the same as those of the original drug. For specific prices and drug details, please consult Yaode’s medical consultant.