The Difference Between Teriflunomide and Dimethyl Fumarate

Teriflunomide (Teriflunomide) and dimethyl fumarate are two different drugs used to treat different types of diseases and have different mechanisms of action and effects. Teriflunomide is mainly used to treat multiple sclerosis (MS). It reduces the symptoms and disease progression of multiple sclerosis by inhibiting the activity of immune cells and regulating inflammatory responses. It inhibits dihydroxyacetyl dehydrogenase (DHODH) to block DNA synthesis, thereby reducing the activity of immune cells. Common side effects include nausea, diarrhea, headache, hypertension, etc.

Dimethyl fumarate is also used to treat multiple sclerosis and is sold under the brand name Tecfidera in some areas. It can play an antioxidant and immunomodulatory role and can reduce inflammatory responses and autoimmune pathological processes. However, the exact mechanism of action is not completely clear, but it is believed to reduce inflammatory responses and regulate the immune system by increasing intracellular antioxidant levels. Common side effects include gastrointestinal discomfort, rash, flushing, low white blood cell count, etc.

The original drug Teriflunomide has been marketed in China and has entered the scope of medical insurance through medical insurance reimbursement standards. It may be limited to patients with multiple sclerosis who are ineffective in conventional treatments. However, the reimbursement ratio is different in different regions, and the price after reimbursement is different. SpecificationsThe price of 14mg*28 tablets per box is about 10,000 yuan. For families with heavy financial burdens, the high price may increase their pressure. Cheaper generic drugs are also sold in other overseas countries. The pharmaceutical ingredients of generic drugs are basically the same as those of the original drugs. The price of 14mg*30 tablets produced by an Indian pharmaceutical factory is around RMB 800 per box (the price may fluctuate due to the exchange rate).