Teriflunomide resistance management

Patients need to obtain transaminase, bilirubin levels, and complete blood count (CBC) within 6 months before starting treatment with teriflunomideTeriflunomideThe recommended dose is 7 mg or 14 mg, taken orally once a day. Monitor alanine aminotransferase (ALT) levels at least monthly for six months after patients start taking teriflunomide. When patients with multiple sclerosis (MS) become resistant, doctors can adjust the dose of teriflunomide and increase or decrease the amount of the drug used to see whether the disease can be effectively controlled.

Doctors may consider combining teriflunomide with other treatments, such as interferons, adenosine, or other immunosuppressants. Combination therapies may provide more powerful immunomodulatory effects to better control the symptoms and progression of multiple sclerosis. Since teriflunomide is the main active metabolite of leflunomide, coadministration with leflunomide is prohibited. Everyone’s constitution is different and their resistance to drugs is also different. If you feel unwell, please inform your doctor in time.

Teriflunomide's Original drug Teriflunomide has been marketed in China and has entered the scope of medical insurance through medical insurance reimbursement standards. It may be limited to multiple sclerosis patients who are ineffective in conventional treatments. However, the reimbursement ratio is different in different regions, and the price after reimbursement is different. SpecificationsThe price of 14mg*28 tablets per box is about 10,000 yuan. For families with heavy financial burdens, the high price may increase their pressure. Cheaper generic drugs are also sold in other overseas countries. The pharmaceutical ingredients of generic drugs are basically the same as those of the original drugs. The price of 14mg*30 tablets produced by an Indian pharmaceutical factory is around RMB 800 per box (the price may fluctuate due to the exchange rate).