Is the domestic price of Teriflunomide expensive?

Teriflunomide (Teriflunomide) is the first oral disease-modifying therapy (DMT) drug approved by the National Medical Products Administration for the treatment of multiple sclerosis (MS), sold under the trade name Aubagio. Teriflunomide is the active metabolite of leflunomide, a drug approved for the treatment of rheumatoid arthritis.

Teriflunomide works by blocking the activity of dihydroorotate dehydrogenase, an enzyme necessary for the growth of activated immune cells (i.e., T cells and B cells). These immune cells are involved in the inflammatory attack that destroys the protective myelin sheath surrounding nerve fibers, a hallmark of multiple sclerosis. By blocking this enzyme, teriflunomide prevents the replication of activated cells without affecting the survival of inactivated and slowly dividing cells. The reduction of activated immune cells is thought to reduce the inflammation caused by multiple sclerosis.

The original drug Teriflunomide has been marketed in China and has entered the scope of medical insurance through medical insurance reimbursement standards. It may be limited to patients with multiple sclerosis who are ineffective in conventional treatments. However, the reimbursement ratio is different in different regions, and the price after reimbursement is different. SpecificationsThe price of 14mg*28 tablets per box is about 10,000 yuan. For families with heavy financial burdens, the high price may increase their pressure. Cheaper generic drugs are also sold in other overseas countries. The pharmaceutical ingredients of generic drugs are basically the same as those of the original drugs. The price of 14mg*30 tablets produced by an Indian pharmaceutical factory is around RMB 800 per box (the price may fluctuate due to the exchange rate).