What are the side effects of Teriflunomide?

Teriflunomide (Teriflunomide) is indicated for the treatment of relapsing forms of multiple sclerosis (MS) in adults, including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease. The benefits of teriflunomide outweigh its risks. In studies, teriflunomide has been shown to reduce relapses and delay progression of disability in people with relapsing-remitting multiple sclerosis. Although the effects were limited, they were considered significant.

In clinical studies, the most common adverse reactions of teriflunomide are headache, increased alanine aminotransferase (ALT), diarrhea, alopecia and nausea. The most common adverse reactions related to discontinuation are increased ALT; thrombocytopenia has been found during the post-marketing use of teriflunomide. , pancreatitis, colitis, drug-induced liver injury (DILI), allergic reactions and angioedema, interstitial lung disease, associated eosinophilia, toxic epidermal necrolysis and Stevens-Johnson syndrome, psoriasis or exacerbation of psoriasis (including pustular psoriasis and nail psoriasis), nail diseases and other adverse reactions.

Teriflunomide The original drug has been launched in China and has entered the scope of medical insurance through medical insurance reimbursement standards. It may be limited to multiple sclerosis patients who are ineffective in conventional treatments. However, the reimbursement ratio is different in different regions, and the price after reimbursement is different. The price of 14mg*28 tablets per box is around 10,000 yuan, which is expensive. Cheaper generic drugs are also sold in other overseas countries. The pharmaceutical ingredients of generic drugs are basically the same as those of the original drugs. The price of each box of 14mg*30 tablets produced by an Indian pharmaceutical factory is around RMB 800 (the price may fluctuate due to exchange rates).