What does baricitinib do?

Baricitinib (Baricitinib) is a Janus kinase inhibitor (JAK inhibitor), mainly used to treat autoimmunity diseases, especially rheumatoid arthritis (RA), rheumatoid arthritis (PsA) and psoriatic arthritis (PsA). Its mechanism of action is mainly by inhibiting the Janus kinase (JAK) signaling pathway.

JAKkinase is a type of enzyme that plays a key role in signaling within cells. When the immune system is activated, cells release inflammatory mediators and cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) and interleukin -23 (IL-23). After these cytokines bind to receptors, they activate JAK kinases, thereby triggering intracellular signaling pathways.

Baricitinib interferes with the signaling process of the immune system by selectively inhibiting the activity ofJAKkinase. Specifically, baricitinib mainly inhibits the activities of JAK1 and JAK2 kinases. These kinases play an important role in immune cells and are involved in regulating inflammatory responses and immune cell proliferation.

By inhibiting the activity ofJAKkinase, baricitinib can reduce the production and release of inflammatory mediators, alleviate the inflammatory response, and improve the symptoms of autoimmune diseases. It reduces joint pain, swelling, and stiffness, improves joint function, and reduces the progression of joint damage.

Baricitinib has been launched in China and is included in medical insurance. Patients can purchase it domestically. Due to different medical insurance reimbursement policies in various places, the reimbursement ratio is also different, and the price is about It costs about 1,200~1,600 yuan. Please consult your local pharmacy or medical insurance bureau for specific prices. Baricitinib has both original and generic drugs abroad. The original drug is mainly Eli Lilly’s original drug, and its price is higher than in China. Generic drugs are mainly Bangladeshi generic drugs, and the price is around 450 yuan. The ingredients of original drugs and generic drugs are basically the same.