When to take Teriflunomide, usage and dosage

Teriflunomide is an immunomodulator with anti-inflammatory properties that inhibits dihydroorotate dehydrogenase (a mitochondrial enzyme involved in de novo pyrimidine synthesis). The exact mechanism by which teriflunomide exerts its therapeutic effect in multiple sclerosis is unknown but may involve a reduction in the number of activated lymphocytes in the central nervous system. Teriflunomide is administered orally, which is considered an advantage over other drugs such as interferonβ-1a. Regarding its safety, side effects are similar to those of the immunosuppressant leflunomide, as leflunomide is converted to teriflunomide in the body.

Before the patient starts treatment with teriflunomideTransaminase, bilirubin levels, complete blood count (CBC), blood pressure need to be obtained within 6 months, and the patient should be screened for latent tuberculosis infection with a tuberculin skin test or a blood test for Mycobacterium tuberculosis infection. The recommended dose of teriflunomide is 7 mg or 14 mg taken orally once daily. Monitor alanine aminotransferase (ALT) levels at least monthly for six months after patients start taking teriflunomide.

The original drug Teriflunomide has been marketed in China and has entered the scope of medical insurance through medical insurance reimbursement standards. It may be limited to multiple sclerosis patients who are ineffective in conventional treatments. However, the reimbursement ratio is different in different regions, and the price after reimbursement is different. Specifications The price of 14mg*28 tablets per box is around 10,000 yuan, which is expensive. Cheaper generic drugs are also sold in other overseas countries. The pharmaceutical ingredients of generic drugs are basically the same as those of the original drugs. The price of each box of 14mg*30 tablets produced by an Indian pharmaceutical factory is around RMB 800 (the price may fluctuate due to exchange rates).