Who should not use Baricitinib?

Baricitinib (Baricitinib) is a specific drug, and the indications and medication groups need to be strictly followed. The following is detailed information about baricitinib contraindications and use in specific populations:

Contraindications of baricitinib:

1.Allergic reaction: People who are allergic to the components of baricitinib or similar drugs should avoid this drug. If you have allergic symptoms, such as hives, shortness of breath, facial swelling, etc., you should stop using it immediately and seek medical help.

2.Severe active infection: Baricitinib may increase the risk of infection. Therefore, the use of baricitinib is not recommended during severe active infections (e.g., pneumonia, peritonitis, etc.).

Medication for specific groups of people:

1.Elderly patients: Elderly patients need to be cautious when using baricitinib because they may have other chronic diseases and drug treatments. Additionally, elderly patients may have reduced renal and hepatic function, requiring more frequent monitoring and dose adjustments.

2.Patients with impaired hepatic function: Baricitinib is mainly metabolized by the liver, so special attention is required when using it in patients with impaired hepatic function. In these patients, the drug metabolism of baricitinib may be affected, so dose reductions or extended dosing intervals may be necessary. Physicians will determine whether baricitinib is suitable for use and the optimal dosage adjustment based on the patient's liver function assessment.

3.Patients with impaired renal function: The dose of baricitinib needs to be adjusted according to the patient’s renal function. In patients with impaired renal function, clearance of the drug may be affected and dose reduction may be necessary. Physicians will determine the optimal dose adjustment based on an assessment of the patient's kidney function.

4.Drug Interactions: Baricitinib may interact with other drugs when used concurrently. Therefore, before using baricitinib, patients should inform their doctor about other medications they are taking, including prescription drugs, over-the-counter drugs, and supplements. Certain drugs may increase baricitinib plasma concentrations or increase drug toxicity, while other drugs may decrease the efficacy of baricitinib. Therefore, doctors need to evaluate the medications their patients are taking concurrently and make adjustments accordingly.

5.Other Special Populations: Baricitinib should be avoided during pregnancy because the potential risk to the fetus is unknown. Baricitinib should also not be used by breastfeeding women because baricitinib may be passed to the baby through breast milk. Additionally, the safety and efficacy of baricitinib in children and adolescents have not been established and its use in this population is not recommended.

Contraindications to baricitinib include hypersensitivity to baricitinib components and severe active infection. Baricitinib should not be used by pregnant women, nursing mothers, children and adolescents, and patients with severe hepatic impairment. In patients with severe renal impairment, dose adjustment may be required. For other specific individual circumstances, the use of baricitinib needs to be carefully considered under the guidance of a physician. It is important that patients consult their physician before using baricitinib to ensure eligibility for use and to reduce potential risks.

Baricitinib has been launched in China and is included in medical insurance. Patients can purchase it domestically. Due to different medical insurance reimbursement policies in different regions, the reimbursement ratio is also different. The price is about 1200~1600 yuan. For specific prices, please consult the local pharmacy or the medical insurance bureau. Baricitinib has both original and generic drugs abroad. The original drug is mainly Eli Lilly’s original drug, and its price is higher than in China. Generic drugs are mainly Bangladeshi generic drugs, and the price is around 450 yuan. The ingredients of original drugs and generic drugs are basically the same.