Why is Trametinib useless after one year of taking it?

Trametinib (Trametinib)The recommended dosage is 2 mg once daily, taken on an empty stomach at least 1 hour before or 2 hours after meals. It usually needs to be taken at the same time every day as much as possible to ensure stable blood concentration of the drug. The effectiveness and duration of trametinib vary based on the individual patient's condition and type of cancer. In some cases, trametinib may lose its effectiveness over a period of time.

If tumor cells develop resistance to trametinib, they may no longer be sensitive to the drug. This resistance may be due to genetic mutations or other mechanisms. Some cancers may develop new mutations or mutations during treatment, resulting in trametinib being unable to effectively inhibit tumor growth and spread. Trametinib may cause a range of side effects, and some patients may discontinue using trametinib due to intolerable or severe side effects.

The original drug of trametinib has been launched in China and has entered the scope of Class B medical insurance, but it may only be purchased by patients who meet the indications of trametinib, such as BRAF V600 mutation-positive unresectable or metastatic melanoma. Its price is around 10,000 to 20,000 yuan. The reimbursement ratio is different in different regions, and the price is also different, making it expensive. The price of the Turkish version of the original drug Trametinib listed overseas is around RMB 7,900 (the price may fluctuate due to the exchange rate). The price of the generic version of Trametinib produced by the Lao pharmaceutical factory is around RMB 2,950 (the price may fluctuate due to the exchange rate). The ingredients and efficacy of foreign generic drugs are basically the same as those of the domestic and foreign original drugs.