What are the functions and efficacy of Trametinib tablets?

Trametinib (Trametinib) is a MEK inhibitor drug. Its main function is to inhibit the RAS/RAF/MEK/ERK signaling pathway in tumor cells. Trametinib is commonly used to treat certain types of malignant tumors, such as advanced or metastatic non-small cell lung cancer, cervical cancer and melanoma with BRAF V600E/K mutations.

Trametinib inhibits the growth, differentiation and proliferation of tumor cells by blocking the signaling of theRAS/RAF/MEK/ERK pathway, thereby slowing down the progression of tumors. Trametinib can reduce the number of tumor cells in the body by inducing apoptosis, that is, cell self-death. Trametinib can also inhibit the invasion and metastasis of tumor cells, reducing the risk of cancer spreading to other sites.

The original drug of trametinib has been launched in China and has entered the scope of Class B medical insurance, but it may only be purchased by patients who meet the indications of trametinib, such as BRAF V600 mutation-positive unresectable or metastatic melanoma. Its price is around 10,000 to 20,000 yuan. The reimbursement ratio is different in different regions, and the price is also different, making it expensive. The price of the Turkish version of the original drug Trametinib listed overseas is around RMB 7,900 (the price may fluctuate due to the exchange rate). The price of the generic version of Trametinib produced by the Lao pharmaceutical factory is around RMB 2,950 (the price may fluctuate due to the exchange rate). The ingredients and efficacy of foreign generic drugs are basically the same as those of the domestic and foreign original drugs.