Are there any complications from Trametinib?

Patients may experience complications during treatment with Trametinib (Trametinib). The treatment of trametinib needs to be taken according to the doctor's instructions, but everyone has different drug resistance properties and different reactions to complications. Patients who are not suitable for taking the medicine should inform the doctor in time.

Trametinib can affect heart function, leading to problems such as hypertension, arrhythmias, and heart failure. Patients may develop myocarditis or cardiomyopathy while taking trametinib, which may lead to cardiac dysfunction. The effects of trametinib are associated with an increased risk of bleeding, including gastrointestinal bleeding, epistaxis, and skin bleeding, immune-related reactions such as pneumonia, thyroid dysfunction, and immune-mediated hemolytic anemia, and visual impairment such as blurred vision, visual field defects, and retinal detachment.

The original drug of trametinib has been launched in China and has entered the scope of Class B medical insurance, but it may only be purchased by patients who meet the indications of trametinib, such as BRAF V600 mutation-positive unresectable or metastatic melanoma. Its price is around 10,000 to 20,000 yuan. The reimbursement ratio is different in different regions, and the price is also different, making it expensive. The price of the Turkish version of the original drug Trametinib listed overseas is around RMB 7,900 (the price may fluctuate due to the exchange rate). Generic trametinib is also produced in other countries. The price of the Lao pharmaceutical factory is around RMB 2,950 (the price may fluctuate due to the exchange rate). The ingredients and efficacy of foreign generic drugs are basically the same as those of domestic and foreign original drugs.