How to take Tofacitinib and what is the dosage?

For adults with rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis, Tofacitinib tablets are usually taken at a dose of 5 mg twice daily; tofacitinib extended-release tablets are usually taken at a dose of 11 mg once daily. Tofacitinib tablets for adult patients with ulcerative colitis are typically administered at 10 mg twice daily for at least 8 weeks, with the patient evaluated based on treatment response and transition to maintenance therapy at 5 mg twice daily for up to 16 weeks. Tofacitinib extended-release tablets are typically taken once daily at 22 mg for at least 8 weeks, transitioning to maintenance therapy at 11 mg once daily for up to 16 weeks. For pediatric patients with polyarticular course of juvenile idiopathic arthritis, the recommended dose of tofacitinib oral solution is weight-related, with 3.2 mg (3.2 ml oral solution) twice daily for patients weighing 10-20 kg, 4 mg (4 ml oral solution) twice daily for patients weighing 20-40 kg, and 5 mg (one 5 mg tablet or 5 ml oral solution) twice daily for patients weighing 40 kg and above.

Tofacitinibhas been launched in China and has entered the scope of Class B medical insurance. The common specification is tofacitinib citrate tablets. The price paid by medical insurance is relatively cheap, but the reimbursement ratio is different in different regions, and the price after reimbursement will be different. Overseas, there are also tofacitinib generic drugs produced in other countries. The price of each box produced by a Bangladeshi pharmaceutical factory is around RMB 300 (the price may fluctuate due to the exchange rate). The ingredients of domestic original drugs and foreign generic drugs are basically the same, and the prices of different specifications will be different.