Reasons why methylcobalamin injection (Rozebalamin) is ineffective in treating tinnitus for six days and suggestions for subsequent adjustments

Methylcobalamin injection (Rozebalamin) is the latest neuroprotective drug developed in Japan for the treatment of amyotrophic lateral sclerosis (ALS, ALS). Its mechanism of action is to promote motor neuron metabolism and myelin repair by providing active vitamin B12 form, thereby delaying neurodegenerative damage. In ALS patients, the drug is mainly used to improve motor nerve function and slow down the progression of muscle atrophy and movement disorders.

If it is used to treat tinnitus or neurological function improvement in ALS related symptoms, it is a common clinical phenomenon that no effect is seen for six days. ALSNeurodegeneration in ALS patients usually develops slowly and complexly, and it takes a long time for nerve repair and functional improvement to be noticeable. If no obvious relief is seen within six days of short-term medication, it does not mean that the medication is ineffective, but that it requires continued use for a longer period of time to exert a neuroprotective effect.

Recommendations for subsequent adjustments include continued long-term use as directed by the doctor, and combined with overall condition assessment for individualized dose management. For ALS patients, methylcobalamin injection generally needs to be continued for weeks to months to observe the efficacy. Doctors may fine-tune the dose based on the patient's weight, disease severity, and tolerance. In addition, rehabilitation training, physical therapy and symptomatic supportive care can be combined to improve muscle function and quality of life.

Clinically, attention should also be paid to the patient's overall neurological status and possible accompanying symptoms. If symptoms do not improve within six days, regular follow-up should be maintained to evaluate motor function, respiratory function and other ALS related indicators. Under the guidance of a doctor, scientifically adjust the treatment course and dosage to ensure the safety and effectiveness of long-term use of the drug, thereby maximizing the potential benefits of methylcobalamin injection in the treatment of ALS.

Keyword tag:

ALS (ALS), neuroprotection, vitaminsB12, nerve repair, clinical trials, drug prices, imported drugs, no generic drugs, regular drug purchase channels

Reference materials:https://pubmed.ncbi.nlm.nih.gov/?term=mecobalamin