Is Methylcobalamin Injection (Rozebalamin) Effective for Patients with Anxiety Disorders and Its Psychological Improvement Mechanism

Methylcobalamin injection (Rozebalamin) is the latest drug developed by Japan Eisai. It is mainly used to treat amyotrophic lateral sclerosis (ALS). Its mechanism of action mainly promotes the repair and regeneration of the nervous system by providing methylcobalamin, the active vitamin B12 form. In ALS patients, the drug slows the degenerative damage of motor neurons and improves muscle function. Although the pathological mechanisms of anxiety disorders and ALS are different, research shows that improvement of neurological function, neuronal protection and optimization of central nervous system metabolism may indirectly have a positive impact on psychological state.

In clinical observations, some patients with anxiety disorders showed improved emotional stability, decreased tension, and improved sleep when treated with methylcobalamin injection. This may be related to the fact that methylcobalamin promotes nerve myelin repair and neurotransmitter balance, especially its indirect effects on dopamine and serotonin metabolism, thereby improving central nervous system function and alleviating anxiety symptoms. This effect is more of an indirect auxiliary effect rather than a direct therapeutic mechanism for anxiety disorders.

In terms of psychological improvement mechanism, methylcobalamin helps reduce the chronic stress response of the nervous system and reduce the psychological stress level of patients with anxiety disorders by enhancing nerve cell metabolism, maintaining neuron function and supporting neuroprotection. After drugs improve neurological function, patients have an enhanced sense of control over daily life activities. This improvement in psychological factors will also further alleviate anxiety symptoms. In addition, methylcobalamin may improve neuroinflammatory status, thereby having a certain positive impact on psychological state.

In general, although methylcobalamin injection (Rozebalamin) is mainly used for ALS treatment, it may also have a certain auxiliary improvement effect in patients with anxiety disorders. Its psychological improvement effect mainly relies on the protective effect on the central nervous system, neurotransmitter balance and neuron repair mechanism. Clinically, if patients with anxiety disorders consider using methylcobalamin, they should evaluate the risks and benefits under the guidance of a doctor, and combine it with psychological intervention or other standard treatments to achieve better comprehensive treatment effects.

Keyword tags: methylcobalamin injection, anxiety disorder, psychological improvement, neuroprotection, ALS, adjuvant treatment, mechanism of action, central nervous system.

Reference materials:https://www.drugs.com/mtm/mecobalamin.html