What are the contraindications for Cabozantinib?

Cabozantinib is a multi-target tyrosine kinase inhibitor that is widely used to treat malignant tumors such as advanced renal cell carcinoma (RCC), hepatocellular carcinoma (HCC), differentiated thyroid cancer (DTC), and pancreatic neuroendocrine tumors (pNET). It achieves anti-tumor effects by inhibiting the kinase activity of multiple receptors such as VEGF and MET, inhibiting tumor angiogenesis, tumor cell proliferation and metastasis. However, although cabozantinib has significant therapeutic effects, it also has certain contraindications and limitations of use.

1. Cabozantinib is contraindicated in patients with known allergies to its components. Any patient who is allergic to the active ingredient or excipients in cabozantinib should avoid using this drug. Anaphylaxis may manifest as rash, itching, difficulty breathing, throat swelling and other symptoms. In severe cases, it may cause anaphylactic shock. Therefore, before taking medication, patients need to inform their doctor whether they have any history of drug allergies.

2. Cabozantinib is not suitable for patients with severe liver function impairment. Because cabozantinib is metabolized by the liver, patients with hepatic insufficiency may have excessive blood concentrations due to incomplete clearance of the drug, thereby increasing the risk of adverse drug reactions. Therefore, when treated with cabozantinib, doctors usually assess the patient's liver function and use caution or adjust the dose in cases of liver dysfunction.

3. Cabozantinib is also contraindicated for pregnant and lactating women. During pregnancy, cabozantinib may cause potential harm to the fetus, including risks of abnormal fetal development. Therefore, pregnant women should avoid using this drug. If a nursing woman needs to use cabozantinib, she must first stop breastfeeding. Since the drug may be passed to the baby through breast milk, it may have adverse effects on the baby.

In short, although cabozantinib is an effective targeted therapy drug, due to its potential contraindications, patients must be treated according to the doctor's recommendations when using it to avoid health risks caused by the side effects or contraindications of the drug.

Keyword tags: Cabozantinib,Cabozantinib, contraindications, allergy, liver function, cardiovascular disease, pregnancy, breastfeeding, bleeding risk

Reference materials:https://medlineplus.gov/druginfo/meds/a616037.html