Differences and connections between tenofovir alafenamide fumarate tablets (Vemlidy) and disoproxil

Tenofovir alafenamide fumarate tablets（Vemlidy/Wellide) and disoproxil (Tenofovir Disoproxil Fumarate (TDF) are two drugs commonly used for Hepatitis Bvirus (HBV) infection and are nucleos(t)ide reverse transcriptase inhibitors (NRTIs). Although they have similarities in the treatment of hepatitis B, there are also some differences in the composition, metabolic process, and tolerability of the drugs.

Tenofovir alafenamide fumarate tablets are a new derivative of tenofovir (Tenofovir), which adopts a more stable chemical structure. This structure allows tenofovir alafenamide fumarate tablets to be absorbed more effectively in the body, thereby reducing the side effects of the drug, especially the effects on the kidneys and bones. In contrast, although disoproxil (TDF) also contains the active ingredient tenofovir, it is an esterified form of tenofovir and needs to be transformed in the body to release the active ingredient. During this process, TDF will accumulate more active pharmaceutical ingredients in the body, which may cause greater burden on the kidneys and bones.

In clinical practice, tenofovir alafenamide fumarate tablets and disoproxil are both used to treat chronic hepatitis B, and their efficacy is roughly the same, and both can effectively inhibit the replication of hepatitis B virus. However, due to the better stability of tenofovir alafenamide fumarate tablets in the body, a lower dose is usually required to achieve the same antiviral effect as TDF. Therefore, tenofovir alafenamide fumarate may be a more appropriate choice for some patients, especially those with kidney problems or risk of reduced bone density.

In terms of side effects, tenofovir alafenamide fumarate tablets are better tolerated than disoproxil disoproxil. Common side effects of dipyrofuran in the treatment of hepatitis B include renal damage, reduced bone density, and gastrointestinal discomfort. Especially when used for a long time, TDF may cause problems such as decreased kidney function and osteoporosis, which is an important issue to consider for patients who require long-term antiviral treatment.

Keyword tags:

Tenofovir alafenamide fumarate, Veride, disoproxil, hepatitis B, nucleoside reverse transcriptase inhibitors, drug comparison, renal damage, therapeutic effect, drug metabolism

Reference materials:https://www.medicines.org.uk/emc/product/2314/smpc