Gefapixant Citrate Overdose Risk Assessment

The risk of overdose with Gefapixant Citrate is clinically relatively low, but remains of high concern. As a P2X3 receptor antagonist, the effect of Gemfapixin is mainly concentrated on peripheral sensory nerves, and theoretically it will not cause central respiratory depression or serious cardiovascular events, which is significantly different from traditional cough medicines. However, in overdose, widespread inhibition of neuroreceptors may exacerbate dysgeusia, oral discomfort, or mild peripheral nerve reactions.

In terms of clinical management, once a suspected overdose occurs, the patient's vital signs and neurological status should be assessed immediately, focusing on heart rate, blood pressure, consciousness, and any worsening sensory abnormalities. In overseas experience, most overdose cases can be resolved safely through symptomatic management and supportive treatment, and do not require specific drug detoxification. It is worth noting that Gemfapixin can be partially eliminated by hemodialysis, which provides a theoretical means of intervention in extreme cases, but is usually only considered when the dose is seriously exceeded or the patient has abnormal vital organ function.

To minimize the risk, patients should strictly adhere to the dosage prescribed by their physician and avoid increasing the dosage on their own or mixing it with other drugs. During treatment, if unusual discomfort occurs, such as aggravation of abnormal taste, persistent oral discomfort, or significant fatigue, you should seek medical evaluation in a timely manner. Overseas clinical practice shows that standardized management and regular follow-up are key measures to ensure the safety and efficacy of Gemfapixin.

Generally speaking, Gemfapixin is mainly used in the long-term management of chronic cough. Although the risk of overdose exists, its safety can still be effectively guaranteed through standardized use and timely intervention. Clinicians should combine lifestyle intervention, trigger control and medication course adjustment during medication to obtain the best long-term efficacy.

Reference materials:https://go.drugbank.com/salts/DBSALT003486