What foods should be avoided while taking lapatinib/Telisa?

While taking Lapatinib (Lapatinib) is a targeted drug used to treat HER2 positive breast cancer . When taking lapatinib, patients should pay special attention to their diet to ensure optimal efficacy of the drug and reduce adverse reactions. Here are the foods and drinks to avoid while taking this medication:

1, High-fat foods

High-fat meals may significantly increase the bioavailability of lapatinib, resulting in excessive drug concentrations. Studies have shown that the absorption efficiency of lapatinib can be increased by approximately 4 times after eating high-fat foods. Therefore, patients should avoid high-fat foods such as fried foods, butter, and fatty meats, and it is recommended to take lapatinib after low-fat or fat-free meals.

2, Grapefruit and its products

Grapefruit contains ingredients that inhibit theCYP3A4 enzyme, which may increase the blood concentration of lapatinib and increase the risk of side effects. To avoid this interaction, patients should completely avoid drinking grapefruit and its products, such as grapefruit juice.

3, Alcohol

Drinking alcohol will increase the metabolic burden on the liver and affect the normal metabolism of drugs, especially the metabolism of lapatinib in the liver. Drinking too much alcohol may make medications less effective or cause liver problems, so alcohol intake should be limited.

4, Caffeine-containing beverages

Beverages with high caffeine content, such as coffee and strong tea, may accelerate drug excretion through diuretic effects, thereby reducing the concentration of lapatinib in the body. Patients should avoid ingesting large amounts of caffeine, especially while taking this medication.

5, Foods high in calcium, iron and aluminum

Foods high in calcium, iron, or aluminum, such as dairy products, red meat, and certain green leafy vegetables, may interact with lapatinib and affect the absorption of the drug. Patients should avoid eating large amounts of these foods at the same time, especially supplements rich in calcium, iron, and aluminum.

While taking lapatinib, patients should avoid high-fat foods, grapefruit, alcohol, caffeine, and foods rich in calcium, iron, and aluminum. These dietary taboos can help improve drug absorption and reduce adverse reactions, thereby optimizing treatment effects.

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Reference materials:https://www.ema.europa.eu/en/documents/product-information/tyverb-epar-product-information_en.pdf