What is the standard dosage of Trientine?

The dosage of Trientine(Trientine) is highly individualized and there is no absolutely uniform fixed standard. The core principle of clinical medication is to dynamically adjust it according to the patient's age, weight, disease severity, and response to treatment, so as to ensure the efficacy while minimizing the risk of long-term medication. This is particularly important in overseas rare disease management.

In adult patients, trientine treatment is usually initiated at the lowest recommended dose to reduce initial adverse effects. In most cases, the total daily dose for adults ranges from 800 to 1,600 mg, taken orally and divided into two to four times daily. This divided administration method helps maintain a relatively stable drug concentration in the body, thereby enhancing the copper chelation effect and improving tolerance. During long-term treatment, doctors will gradually adjust the dose based on the patient's clinical response, laboratory monitoring results, and overall disease control, striving to achieve the lowest effective dose.

Pediatric patients generally receive lower doses than adults, depending on age and weight. A relatively conservative dosage strategy is often adopted in the initial stage of treatment, with a common starting range being between 400 and 1000 mg per day. As treatment progresses, doctors will make individual adjustments to the dose based on the child's growth and development and disease control effects. Because the metabolic characteristics of pediatric patients are different from those of adults, follow-up and monitoring are particularly important during medication.

In terms of administration method, trientine is only for oral administration. The capsules must be swallowed whole with water and cannot be chewed or opened. The time of taking the medicine has an important impact on the efficacy, and it is usually required to be taken on an empty stomach, that is, at least one hour before or two hours after a meal. In addition, trientine should be taken at least one hour apart from other medications, food, or milk to avoid affecting its absorption in the intestines. This medication detail is particularly critical in long-term treatment and is directly related to the stability of treatment and the sustainability of efficacy.

Reference materials:https://en.wikipedia.org/wiki/Triethylenetetramine