Possible health risks and treatment methods of aprocitentan overdose

Overdose of aprocitentan, a drug used to treat pulmonary hypertension and related cardiovascular disease, may pose significant health risks. First of all, overdose may cause blood pressure to drop excessively, causing symptoms such as dizziness, fatigue, syncope, and even shock. For patients with cardiac dysfunction, this blood pressure fluctuation may increase the burden on the heart and increase the risk of heart failure or arrhythmia.

Secondly, excessive use of aprecitentan may affect kidney function. When the drug accumulates too much in the body, it may cause electrolyte disorders such as blood sodium and blood potassium, and increase the possibility of renal function damage. For patients with existing renal insufficiency, the risk is particularly obvious and special attention needs to be paid to changes in blood chemistry indicators.

In the event of an overdose, the first step is to seek immediate medical attention and inform the medical staff of the exact dosage and time to take the medication. The doctor may take symptomatic treatment according to the situation, such as intravenous rehydration, monitoring blood pressure and heart rate, correcting electrolyte imbalance, etc. In addition, further medication needs to be suspended and close clinical observation is required to prevent complications.

The key to preventing overdose is to strictly follow your doctor's instructions and avoid increasing or decreasing the dose on your own. Family members should assist patients in managing medications, ensuring daily dosages are accurate, and regularly reviewing blood pressure and kidney function. During the use of aprexitentan, reporting any abnormal symptoms in a timely manner can effectively reduce the health risks caused by overdose and ensure the safety of treatment.

Reference materials:https://pubmed.ncbi.nlm.nih.gov/40853274/