Dosage and correct way of taking Atrasentan

Atrasentan is a selective endothelin receptor antagonist, mainly used to treat diseases related to the immune system, especially in the treatment of chronic kidney disease, which has received widespread attention. Its mechanism is by inhibiting the activity of endothelin receptors, thereby reducing inflammation and fibrosis caused by kidney disease, helping to reduce proteinuria levels and improving kidney function. Atrasentan is an oral drug commonly used to treat primary immunoglobulin A (IgA) nephropathy and other kidney diseases, especially those with significant proteinuria.

For adult patients, the usual dose of atrasentan is usually 0.75 mg once daily. This drug should be taken according to the specific instructions of your doctor, and the dosage should be adjusted based on the patient's health and changes in the condition. When starting treatment, it is generally recommended to start with a lower dose and then gradually increase to the target dose to minimize potential side effects. Typically, the maintenance dose is 0.75 mg once daily until the disease is under control or the patient experiences adverse reactions.

The correct way to take the medicine is to take the medicine directly orally. You can choose to take it with food, but in order to ensure maximum absorption, it is recommended to take it regularly according to the doctor's advice. Atrasentan should be avoided in combination with other drugs that may interfere with its effects, especially certain antihypertensive drugs or drugs that are metabolized by the liver. Therefore, before starting treatment, patients should inform their doctors about their current medication status so that treatment options can be adjusted.

Atrasentan should not be discontinued suddenly, especially if the patient is in the early stages of treatment. Sudden discontinuation of medication may result in rebound of the condition or other side effects. Patients are advised to consult their doctor and proceed step by step when adjusting dosage or stopping medication.

Reference materials:https://en.wikipedia.org/wiki/Atrasentan