Why does Trelagliptin become less effective after taking it?

Trelagliptin (Trelagliptin) is an oral antidiabetic drug that belongs to the dipeptidyl peptidase-4 (DPP-4) inhibitor class and is used to treat type 2 diabetes . The drug inhibits DPP-4 enzyme, extending the half-life of gastrointestinal hormones such as GLP-1 (glucagon-like peptide-1), thereby enhancing insulin secretion and inhibiting glucagon secretion, helping to reduce postprandial and fasting blood sugar levels.

Although tretagliptin shows significant efficacy in many patients, some patients may experience less effective treatment, which may be caused by a variety of factors.

First of all, drug tolerance is an important factor affecting the efficacy of trolagliptin. Over time, a patient's body may adapt to the drug's mechanism of action, causing the drug to become less effective. Especially for patients who have long-term use of DPP-4 inhibitors, the effect of the drug may gradually weaken. At this time, the treatment plan may need to be adjusted, combined medication added, or other therapeutic drugs replaced.

Secondly, the patient's lifestyle may also affect the effectiveness of the drug. For example, factors such as improper diet, lack of exercise, and obesity may lead to poor blood sugar control and inability to fully exert the effects of medications. Therefore, while taking trolagliptin, patients also need to maintain healthy eating habits and lifestyle to help the drug better control blood sugar.

In addition, individual differences are also an important factor leading to variation in efficacy. Each patient's internal environment is different, and factors such as liver and kidney function, metabolic rate, complications, etc. may affect the absorption, distribution, metabolism, and excretion processes of drugs. If the patient's liver and kidney function are impaired, the metabolism of the drug may be affected, resulting in suboptimal blood sugar control.

Finally, the quality of the drug and how it is used may also affect the effectiveness of treatment. Trelagliptin is a drug that requires long-term use. During use, patients may forget to take the drug on time, have inappropriate dosage, or have quality problems with the drug itself, resulting in failure to effectively control blood sugar. Regular follow-up visits and medication adjustments are key to ensuring drug efficacy.

Reference materials:https://go.drugbank.com/drugs/DB15323