What are the worst side effects of Dasatinib/Startaxed?

Dasatinib (Dasatinib) is a targeted therapy drug that is widely used to treat chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). Although it has significant efficacy in treating these leukemia types, its side effects cannot be ignored. The worst side effects often include serious cardiovascular effects, lung disease, bleeding tendencies, and other systemic adverse effects.

First of all, cardiovascular adverse reactions are one of the most vigilant side effects during dasatinib treatment. Studies have shown that dasatinib may cause serious cardiovascular events, such as heart failure, pericardial effusion, pulmonary hypertension, etc. In some severe cases, patients may develop symptoms of heart failure, which is particularly dangerous for patients with pre-existing cardiovascular disease risks. Therefore, doctors often closely monitor patients' cardiovascular health when using dasatinib, especially in patients with a history of heart disease, who must use it with greater caution.

Second, lung problems are another serious side effect associated with dasatinib. Pulmonary hypertension and interstitial lung disease, in particular, may cause difficulty breathing, persistent cough, or chest pain in some patients. Long-term pulmonary symptoms may affect a patient's quality of life or even be life-threatening. Therefore, patients with lung discomfort should stop taking the drug immediately and undergo further examination.

Dasatinib may also cause severe bleeding. Some patients may experience symptoms such as nosebleeds and gastrointestinal bleeding, which often occur early in treatment and may worsen if left untreated. In addition, dasatinib may cause thrombocytopenia, further exacerbating the risk of bleeding. Therefore, patients need to have regular blood tests while taking dasatinib to ensure that platelet values u200bu200bare within the normal range.

Reference materials:https://go.drugbank.com/drugs/DB01254