What will happen to your body after taking neratinib/neratinib (He Li'an) for one year?

Neratinib is commonly used in the treatment of breast cancer, particularly as intensive adjuvant therapy for patients with HER2-positive early-stage breast cancer. A common treatment regimen for this drug is 240 mg (6 tablets) taken orally once daily for one year. The reason this treatment lasts for one year is because clinical studies have shown that long-term use of neratinib can effectively reduce the risk of recurrence in patients with HER2-positive breast cancer, especially in patients with early-stage breast cancer.

Patients may experience some side effects while taking neratinib. According to clinical research and use experience, common side effects of neratinib include diarrhea, nausea, loss of appetite, fatigue, etc. These side effects may be more obvious at the beginning of treatment, but usually as treatment continues, the patient's body will gradually adapt and some symptoms will reduce or disappear.

Regarding diarrhea, patients with neratinib tend to experience some degree of diarrhea early on. Diarrhea is a common side effect of neratinib, especially during the first few weeks of treatment. The diarrhea symptoms of most patients are more obvious in the early stages of treatment, and will be relieved as the treatment time prolongs. However, it should be noted that patients need to effectively manage symptoms such as diarrhea under the guidance of a doctor. Commonly used management methods include using antidiarrheal medications, maintaining fluid intake, and adjusting the dose of neratinib based on the severity of symptoms.

In addition to diarrhea, long-term use of neratinib may also cause other uncomfortable symptoms, such as oral ulcers, abnormal liver function, and skin reactions. Most patients are able to manage and achieve relief with the help of their doctor during treatment, which can help improve quality of life and maintain treatment continuance.

Patients taking neratinib for a long time should also undergo regular blood tests and liver function tests to ensure that the side effects of the drug can be detected and dealt with in time. During treatment, patients should maintain good communication with the doctor and report any uncomfortable symptoms or side effects so that the doctor can adjust the treatment plan according to the specific situation.

References:https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-neratinib-metastatic-her2-positive-breast-cancer