Which company develops and produces Belumosudil tablets and what is its background?

Belumosudil mesylate tablets (Belumosudil), trade name Rezurock, is developed and produced by Kadmon Pharmaceuticals. Kadmon Pharmaceuticals is a biopharmaceutical company focused on developing innovative drugs. It was founded in 2010 and is headquartered in the United States. The company is committed to solving unmet medical needs in the fields of cancer, immunology and genetics, and has developed several important drugs, one of which is besudil. In 2021, Kadmon Pharmaceuticals was acquired by Sanofi, a world-renowned pharmaceutical company, and became a wholly-owned subsidiary of Sanofi, further enhancing its innovation capabilities in the field of biopharmaceuticals.

The development background of Besudil Tablets stems from concerns about the need for treatment of chronic graft-versus-host disease (GVHD). GVHD is a serious complication that commonly occurs in patients who receive a hematopoietic stem cell transplant (such as a bone marrow transplant). During the transplant process, the donor's immune system attacks the recipient's healthy tissues, leading to a series of immune reactions, including damage to organs such as the skin, liver, and gastrointestinal tract. Although traditional treatments, such as glucocorticoids and other immunosuppressive drugs, can provide some relief in many patients, for some patients, these treatments have limited effectiveness and are accompanied by significant side effects.

Besudil tablets, as a kinase inhibitor, can effectively inhibit a variety of enzymes related to immune response, reduce the overreaction of the immune system, thereby alleviating the symptoms of GVHDGVHD. The success of its research and development has brought new treatment options to patients with refractory GVHD and laid the foundation for Kadmon Pharmaceuticals' future development. The marketing of Besudil has further received Sanofi's strong financial support and global resource integration, allowing it to be launched and widely used in more countries and regions.

Reference materials:https://www.drugs.com/mtm/belumosudil.html