How long does it take to see significant weight loss or hypoglycemic effects of Tilpotide/Tilsipatide (Mufengda)?

Tirzepatide/Tisiparatide (Tirzepatide) is a dual receptor agonist that achieves blood sugar control and weight management by acting on both GIP and GLP-1 receptors. In clinical studies, patients' blood sugar and weight improved with a certain time pattern after taking tilsiparatide. Usually, the initial changes in the hypoglycemic effect can be observed in the first to second weeks after taking the drug, which is mainly manifested as a slight decrease in fasting blood sugar and postprandial blood sugar. The effects at this stage are relatively mild and need to be combined with lifestyle intervention to stabilize blood sugar levels.

For weight management, tilsiparatide works slightly slower than glycemic improvement. Clinical data show that most patients begin to experience significant weight loss after four to eight weeks of taking the drug, accompanied by a decrease in appetite and meal intake. The extent of weight loss is related to the patient's starting weight, lifestyle and dose. Patients with high doses usually have more obvious weight loss effects. Weight changes may be slower in the early stages, but cumulative effects are achieved with continued use.

In terms of medium and long-term efficacy, clinical trials show that most patients can lose weight by 5% to 15% after continuous use for 12 to 26 weeks, and blood sugar control can be significantly improved. A downward trend in HbA1c levels can be observed in about 12 weeks of medication, and it often takes about 3 months to achieve significant improvement in weight loss. At this stage, patients should cooperate with a healthy diet and moderate exercise to improve the efficacy and maintain long-term weight loss.

It should be noted that tilsiparatide varies among individuals. Some patients may have faster effects, while others may take longer to show significant effects. Gastrointestinal discomfort such as nausea and vomiting may occur during use. These symptoms usually appear in the early stages of medication and gradually reduce with adaptation. In order to achieve the best weight loss and hypoglycemic effects, patients should strictly follow the doctor's instructions when using medications, and regularly follow up on blood sugar and weight changes to ensure that efficacy and safety are achieved simultaneously.

Reference materials:https://pubmed.ncbi.nlm.nih.gov/36251836/