What should I do if my blood pressure does not improve after taking Talazoparib (Tazena) for three days?

Talazoparib is an oral PARP inhibitor, mainly used to treat breast cancer patients carrying BRCA gene mutations. The main mechanism of action is to induce tumor cell apoptosis by inhibiting DNA repair enzyme PARP. However, talazoparib is not an antihypertensive drug and its main role is not in blood pressure control. Therefore, if the patient's blood pressure does not improve after three days of taking it, this may not be directly related to the therapeutic effect of the drug itself, and needs to be analyzed from the perspective of the overall condition and management of accompanying diseases.

In cases where blood pressure does not improve, the patient should first be evaluated for pre-existing hypertension or concomitant cardiovascular disease. If the patient has a history of hypertension, talazoparib will not replace antihypertensive medications. At this time, you should continue to follow the original antihypertensive treatment plan, monitor changes in blood pressure, and adjust the dosage of antihypertensive drugs or change drugs according to medical advice. At the same time, attention should be paid to lifestyle management, such as low-salt diet, weight control, appropriate exercise, and avoiding excessive mental stress. These measures can help stabilize blood pressure.

Secondly, the possible indirect effects of talazoparib need to be investigated. For example, some patients may experience dehydration, vomiting, or loss of appetite while taking the medication, and these factors may cause blood pressure to fluctuate or become unstable. Therefore, during medication, one should maintain adequate fluid intake, pay attention to electrolyte balance, and observe changes in blood pressure at any time. Once significant increases in blood pressure or other symptoms of cardiovascular discomfort occur, a doctor should be contacted promptly for evaluation and intervention.

Finally, while patients are taking talazoparib, they should regularly follow up and monitor relevant indicators, including blood pressure, heart rate, and blood routine. Doctors will adjust the treatment plan based on the patient's overall condition to ensure that tumor treatment and concomitant disease management are synchronized. If blood pressure problems persist or worsen, you should seek medical attention immediately to evaluate whether antihypertensive medications need to be adjusted or other cardiovascular interventions are needed to ensure medication safety and therapeutic effectiveness.

Reference:https://en.wikipedia.org/wiki/Talazoparib