Optimum administration time of dasatinib/tasatinib

Dasatinib (Dasatinib) is a multi-target tyrosine kinase inhibitor, mainly used to treat chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL). As a precision targeted drug, its pharmacokinetic characteristics are closely related to the way it is taken. The correct administration time and method are crucial for stable drug efficacy and control of adverse reactions.

The taking time of dasatinib is flexible and can be taken in the morning or evening and is not affected by food. In other words, patients can take the medicine with food or on an empty stomach, which is different from some targeted drugs that need to be taken strictly on an empty stomach or after meals. However, doctors usually recommend that patients choose to take it at a fixed time to maintain the stability of drug concentrations in the body, which is especially critical for long-term treatment of chronic diseases.

In terms of specific taking methods, dasatinib tablets must be swallowed whole and cannot be crushed, cut, or chewed. This is because the formulation structure of the drug is precisely designed, and damaging the tablet will affect its absorption speed and bioavailability, thereby changing the drug concentration in the body and increasing the risk of side effects. Especially for children or patients with swallowing difficulties, doctors will develop alternative plans based on individual circumstances and do not recommend changing the status of tablets without authorization.

The medicine should be taken with an appropriate amount of water to help the medicine enter the stomach smoothly and reduce gastric mucosal irritation. If the patient experiences stomach discomfort, the medication time can be appropriately adjusted, for example, taking it half an hour after a meal, which can reduce the burden on the stomach without affecting absorption. In addition, simultaneous use with acid-suppressing drugs (such as omeprazole, ranitidine, etc.) should be avoided because these drugs will change the gastric acid environment and reduce the absorption rate of dasatinib, thus affecting the efficacy.

It is worth noting that dasatinib is a targeted therapy drug that needs to be taken for a long time, and its mechanism of action determines that the persistence of blood concentration is extremely important. Long-term interruption or frequent changes in medication time may lead to unstable efficacy and even induce drug resistance.

Reference materials:https://www.ema.europa.eu/en/medicines/human/EPAR/sprycel