Common side effects of aprocitentan and how to identify their symptoms

Aprecitentan is a new endothelin receptor antagonist mainly used to treat refractory hypertension. During clinical use, patients may experience some common side effects, which need to be identified and dealt with in a timely manner. The most common side effects include headache, fatigue, peripheral edema and mild hypotension. Most of these symptoms are mild to moderate and can generally be alleviated by adjusting the dose or improving lifestyle. Patients should pay attention to uncomfortable changes in their body during daily medication, especially persistent or worsening symptoms.

Some patients may experience edema after taking aprecitentan, such as edema of the lower limbs or slight swelling of the face. Such symptoms are usually more likely to occur in the early stages of medication, and patients can self-monitor by measuring weight changes, observing indentations on the lower limbs, and recording symptoms daily. If edema is obvious or accompanied by dyspnea, you should seek medical treatment promptly, and the doctor will evaluate whether dosage adjustment or diuretic measures need to be taken to avoid further cardiovascular burden.

Headache and fatigue are also common side effects of aprecitentan. Headaches are mostly mild to moderate and can be relieved by resting, maintaining good sleep, and being properly hydrated. Fatigue is characterized by easy fatigue or decreased energy during daily activities. Patients can improve symptoms by gradually increasing the amount of activity, regular work and rest, and nutritional support. If symptoms persist or affect quality of life, you should report it to your doctor to determine whether medication adjustments or combination therapy are needed.

In general, the side effects of aprecitentan are relatively controllable in clinical use, but patients should remain vigilant and learn to self-observe and record symptom changes. By early identification of mild to moderate side effects, such as edema, headache, and fatigue, and timely communication with doctors, adverse reactions can be effectively managed, medication safety ensured, and ideal blood pressure control effects achieved.

Reference materials:https://pubmed.ncbi.nlm.nih.gov/40853274/