Pegcetacoplan-Empaveli Drug Interactions and Precautions

As a complement inhibitor, drug interactions and precautions for Pegcetacoplan are very important because it involves the regulation of the immune system and may interact with other drugs or disease states.

Interactions with other drugs are relatively rare, but because its mechanism of action involves the complement system, special caution is required when used in combination with immunosuppressants, anti-infectives, or other immune system-related treatments. For example, coadministration of pegnazumab with certain immunosuppressants (such as cyclosporine, tacrolimus, etc.) may increase the risk of infection, especially bacterial, fungal, and viral infections. Therefore, patients should avoid concurrent use of medications that suppress the immune system while taking Pegtak, except under strict supervision by a physician.

In addition, the use of PEGATOX should be avoided with certain anticoagulant drugs (such as warfarin, direct oral anticoagulants, etc.) because these drugs may increase the risk of bleeding. As an immunomodulatory drug, Pegtak inhibits the complement system and may affect blood coagulation function. It needs to be used with caution in clinical practice, especially in patients with bleeding tendencies.

Physicians should monitor patients regularly while using PEGATOX, especially blood tests and kidney function monitoring. Pegasus may have effects on renal function, particularly when treating C3G or IC-MPGN, requiring periodic assessment of urine protein levels and glomerular function.

Since the metabolism of Pegtak depends on the liver, regular monitoring of liver function is required during long-term use to ensure that patients do not show signs of liver damage. Although allergic reactions to pegnata are rare, allergic reactions such as rash, itching, and difficulty breathing may occur in some patients. Patients who develop these symptoms while taking Pegtak should seek medical attention immediately.

Reference materials:https://empaveli.com/