Anagrelide dosage and specific dosage instructions

The use of anagrelide (Anagrelide) depends on the specific conditions of the patient. The dosage adjustment needs to be determined based on the platelet count and drug resistance of patients with essential thrombocythemia (ET). The following are common dosage and dosage instructions for adult and pediatric patients.

For adult patients, the usual starting dose of anagrelide is 0.5 mg 4 times a day or 1 mg 2 times a day. This dose is usually continued for one week and can be gradually adjusted based on the patient's platelet count. Weekly dose increases should not exceed 0.5 mg/day. Continue to adjust the dose until the platelet count remains within the normal range. Usual maintenance doses are 1.5-3 mg/day, with maximum doses up to 10 mg/day. This dosage range is designed to balance the efficacy of the drug with the risk of side effects to ensure the safety and effectiveness of the treatment.

In patients with impaired hepatic function, especially those with mild to moderate hepatic impairment, the starting dose should be lower. The recommended starting dose is 0.5 mg/day and should be adjusted based on the patient's specific condition. In patients with severely impaired liver function, anagrelide is generally not recommended or must be used under close supervision by a physician.

Anagrelide is also used in children similarly to adults. For children, the starting dose is 0.5 mg/day, which also needs to be continued for one week and adjusted based on platelet count. As in adults, the dose should not be increased by more than 0.5 mg/day until platelet counts are achieved. The usual maintenance dose for children is similar to that for adults, usually 1.5-3 mg/day, with a maximum dose of 10 mg/day. Likewise, dose adjustments in pediatric patients should be made with caution, especially in the setting of impaired hepatic function.

Reference materials:https://go.drugbank.com/drugs/DB00261