List of dietary contraindications for Pyrotinib/Areni

Pyrotinib Maleate (Pyrotinib Maleate) is an oral small molecule irreversible tyrosine kinase inhibitor (TKI) that mainly acts on the epidermal growth factor receptor 2 (HER2) and EGFR pathways and is widely used in the treatment of HER2-positive breast cancer. As a targeted drug, pyrotinib may be affected by diet and drug interactions during absorption and metabolism. Therefore, mastering dietary taboos is crucial to ensure efficacy and safety.

First of all, patients should avoid high-fat and high-calorie foods while taking pyrotinib, especially taking the medicine immediately after eating. Although this product can be taken with meals, excess fat will delay gastric emptying and may affect the rate of drug absorption, resulting in fluctuations in blood drug concentration. Studies have shown that eating an overly greasy diet will slow down the time it takes to reach Cmax of pyrotinib, which may have a certain impact on the efficacy. In addition, alcohol consumption needs to be cautious. Alcohol may not only increase the hepatic metabolism burden of the drug, but may also increase adverse drug reactions, such as abnormal liver function and gastrointestinal symptoms. Therefore, it is recommended that patients avoid drinking alcohol while taking the drug.

Secondly, the intake of products containing grapefruit and its derivatives needs to be strictly limited. The active ingredients contained in grapefruit can inhibit the activity of CYP3A4 enzyme, and pyrotinib is mainly metabolized through the CYP3A pathway. Grapefruit may increase drug blood levels, thereby increasing the risk of adverse reactions, including diarrhea, rash, and elevated liver enzymes. Patients should read food labels carefully while taking the medication and avoid consuming juices, candies or health products containing grapefruit ingredients.

Furthermore, patients should pay attention to interactions with other drugs and herbal medicines during medication. In particular, Chinese herbal medicines such as astragalus and salvia miltiorrhiza may affect the metabolism of pyrotinib by inducing or inhibitingCYP enzymes. At the same time, supplements containing high amounts of vitamins or minerals may have a certain impact on the gastrointestinal absorption of drugs. It is recommended to use them appropriately under the guidance of a professional doctor.

In short, the dietary management of pyrotinib should be based on the principles of balance, lightness, and easy digestion, avoid high-fat, high-sugar and irritating foods, and stay away from alcohol and grapefruit products to ensure the efficacy and safety of the drug.

Reference materials:https://synapse.patsnap.com/article/what-is-pyrotinib-maleate-used-for