What specific symptoms can Apremilast (Otelor) improve in patients with psoriasis?

Apremilast (Apremilast) is an oral small-molecule phosphodiesterase 4 (PDE4) inhibitor. It mainly works by regulating the inflammatory response of the immune system in the treatment of psoriasis. The drug can inhibit the secretion of pro-inflammatory cytokines such as TNF-α, IL-17 and IL-23 while increasing the anti-inflammatory cytokine IL-10 levels, thereby improving typical symptoms of skin inflammation, erythema and scales. Clinical data shows that patients taking Apremilast can observe relief of skin symptoms within a few weeks, especially in patients with moderate to severe plaque psoriasis.

In addition to improving skin inflammation, Apremilast also has a certain effect on relieving the itching and pain associated with psoriasis. Itching is one of the most troublesome symptoms for psoriasis patients, and long-term presence can affect sleep and quality of life. By inhibiting inflammatory mediators, Apremilast can significantly reduce itching and improve patients' daily life experience. In addition, it can relieve skin pain and burning sensation, helping patients better carry out daily activities and self-care.

In terms of joint symptoms, Apremilast also has a positive effect on psoriatic arthritis. The drug reduces joint pain, swelling, and stiffness and improves joint mobility and performance. Clinical studies have shown that some patients have significant relief of joint symptoms and improved quality of life and mobility after several weeks of treatment. This is particularly important for psoriasis patients with arthritis, as long-term uncontrolled joint damage may lead to functional impairment and even disability.

In general, Apremilast can improve various symptoms of psoriasis patients, including skin erythema, scales, itching, pain and joint discomfort. Its oral administration method, high safety and good tolerability enable patients to maintain treatment for a long time, thereby controlling disease progression and improving quality of life. In clinical applications, doctors usually adjust the dosage according to the severity of patients' symptoms and individual differences to ensure both efficacy and safety.

Reference materials:https://www.fda.gov/