What examinations and monitoring items need to be done before taking Biken Pronol Tablets (Bituvi)

Before taking Biktarvy tablets (Biktarvy), patients need to undergo a comprehensive assessment and basic examination to ensure safe medication use and efficacy monitoring. First, the diagnosis and virological status of HIV infection should be confirmed, including plasma HIV-1 RNA levels and CD4+ lymphocyte counts. Blood viral load and immune status are important basis for judging whether to start antiviral treatment, and also provide baseline data for subsequent efficacy monitoring.

Basic liver and kidney function tests should be performed. BiktarvyContains bictegravir, prenoxivir and tenofovir allatelate (TAF). The metabolism of these drugs in the body mainly depends on the liver, and is partially excreted by the kidneys. Patients with abnormal liver function may be at increased risk of drug toxicity, while patients with renal insufficiency need to carefully adjust the dose or choose an alternative. Therefore, indicators such as serum ALT, AST, total bilirubin, serum creatinine and glomerular filtration rate (eGFR) must be evaluated before medication.

Patients should undergo basic hematology and lipid metabolism assessment. HIV Long-term use of antiviral drugs by HIV patients may affect blood cell production and lipid metabolism, and increase cardiovascular risks. Therefore, complete blood picture and blood lipid profile examination can provide reference for safety monitoring after medication, so as to facilitate timely detection of potential abnormalities and intervention during the course of treatment. In addition, hepatitis B virus (HBV) and hepatitis C virus (HCV) screening is also necessary to avoid potential viral relapse or worsening of liver injury.

Previous medication history and possible drug interactions need to be evaluated. Biktarvyis metabolized through CYP3A and UGT1A1 pathways. If patients use strong CYP3A inhibitors or inducers at the same time, it may lead to an abnormal increase or decrease in blood concentration, thus affecting efficacy or safety. Doctors usually collect information about all prescription drugs, over-the-counter drugs and health care products from patients and make personalized adjustments. Based on the above inspection and evaluation, we can lay the foundation for the safe and effective use of Bikeren Pronol tablets.

Reference materials:https://www.drugs.com/