Detailed description of the scope of indications for Futibatinib

Futibatinib(Futibatinib) is a highly selective FGFR inhibitor with clear molecular targeting characteristics. Its indication setting is not suitable for all cholangiocarcinoma(CCA) patients. According to international drug standards, forbatinib is mainly used for adult patients with unresectable locally advanced or metastatic intrahepatic cholangiocarcinoma who have received previous treatment and whose disease has progressed. This positioning reflects the in-depth application of the precision treatment concept in the field of biliary tumors.

In determining indications, the core prerequisite is that the tumor must carry fibroblast growth factor receptor2 (FGFR2) gene fusion or other rearrangements. This molecular abnormality is specific to intrahepatic cholangiocarcinoma and is also one of the important mechanisms driving tumor growth. Forbatinib interferes with tumor cell proliferation and survival from the source by irreversibly inhibiting the FGFR signaling pathway, providing targeted treatment opportunities for this specific population.

It should be emphasized that forbatinib is not suitable for patients who have not experienced FGFR2 fusion or rearrangement. Therefore, patients usually need to undergo standardized molecular testing to clarify their genetic status before considering taking medications. This test result is not only related to whether forbatinib can be used, but also helps doctors develop more precise follow-up treatment strategies for patients.

Judging from overseas clinical practice, forbatinib is mostly used in the second-line or later-line treatment stage, especially for patients who have previously received chemotherapy or other systemic treatments but had limited efficacy. For this group of people, the significance of forbatinib is not only to delay disease progression, but also to obtain more treatment window periods for patients.

In general, the scope of indications for fobatinib is clear and concentrated, emphasizing the three core keywords of "intrahepatic cholangiocarcinoma", "previous treatment failure" and "FGFR2 fusion or rearrangement". For eligible patients, it represents an important treatment option in the context of precision medicine.

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