Correct usage, dosage and taking time of Stiripentol

The dosage of Stiripentol has obvious individual characteristics, especially in children and adolescent epilepsy patients. The medication regimen usually needs to be finely adjusted based on weight, age and combined medication. The target dose generally recommended by overseas medication data is 50 mg/kg per day, which is administered orally and divided into 2 or 3 times a day according to the patient's specific conditions to ensure that the blood concentration is relatively stable and thereby improve the anti-epileptic effect.

In terms of dosage form selection, stiripentol is commonly available in capsule form. The capsules should be swallowed whole with plenty of water. It is not recommended to break, crush or chew the capsules. This is particularly important to ensure drug release characteristics and absorption stability. According to overseas instructions and medication experience, stiripentol should be taken with meals, which can help improve gastrointestinal tolerance and reduce gastric discomfort or loss of appetite in some patients.

Regularity in taking medication is also critical. It is recommended that patients take medication within a relatively fixed time period every day to reduce fluctuations in blood concentration. For patients who need to take the medication in three doses, a reasonable allocation of morning, noon and evening medication times will help maintain a sustained anti-epileptic effect throughout the day. If you occasionally miss a dose, it is generally not recommended to double the dose on your own. Instead, you should consult a doctor as soon as possible or continue the next dose according to the established plan.

Special caution is required regarding discontinuation or dose adjustment of stiripentol. Whether it is due to efficacy evaluation, tolerability issues, or changing treatment regimens, the discontinuation process should adopt a gradual dose reduction method to avoid sudden discontinuation. Sudden discontinuation of medication may lead to a significant increase in the frequency of epileptic seizures and even induce severe seizures, so slow tapering is an important principle in the international consensus on medication.

Reference materials:https://www.diacomit.com/