What foods should be avoided while taking Eltrombopag (Revlan)?

Eltrombopag is an oral TPO receptor agonist. It is easily affected by divalent and trivalent cations (such as calcium, iron, magnesium, aluminum, etc.) during the gastrointestinal absorption process. Therefore, you need to avoid high-calcium and mineral-fortified foods during medication, including milk, milk powder, cheese, yogurt, calcium tablets, calcium supplement drinks, etc. If these foods are taken at the same time before and after taking the medicine, the absorption of the medicine will be significantly reduced and the platelet-raising effect will be weakened. It is generally recommended to avoid consuming calcium-containing foods or calcium supplements for at least 2 hours before and after taking medication. Maintaining an empty stomach or a light state is more conducive to stable drug absorption.

In addition to dairy products, supplements and foods high in minerals such as iron, magnesium, and aluminum also require special attention. For example, iron-fortified cereals, iron supplements, magnesium-containing antacids, some mineral drinks, etc. These metal elements will form insoluble complexes with the drugs, causing eltrombopag to be unable to be absorbed normally, thus affecting the efficacy. If you really need to supplement iron or magnesium-containing products, it is best to wait at least 4 hours between taking eltrombopag and eltrombopag to reduce absorption interference. It is also not recommended to drink high-mineral functional drinks or "high-calcium and high-iron" health drinks while taking the medicine.

In addition, you should avoid excessive intake of high-fat and greasy foods when taking eltrombopag Although fat will not directly complex with drugs, it will delay gastric emptying and make drug absorption unstable. Some patients may experience delayed or reduced absorption, thus affecting the rate of platelet rise. At the same time, patients with mild liver function abnormalities may experience nausea, fatigue and other discomforts after ingesting oily foods, which will aggravate the adverse reactions during medication. Therefore, it is recommended to adopt a light diet and low-oil cooking mode to maintain stable medicinal effects.

Finally, you need to avoid Grapefruit (grapefruit) and its products, including grapefruit juice, grapefruit jam, etc. Grapefruit inhibits liver metabolic enzymes and transporters, which may increase the concentration of eltrombopag in the body and increase the risk of adverse reactions, such as elevated liver enzymes, headache or fatigue. Although the literature is not entirely consistent on the extent of its impact, clinical recommendations generally suggest avoiding such foods. In addition, you should maintain a regular diet and avoid excessive alcohol during the medication to reduce the burden on the liver and make the treatment safer and more effective.

Reference materials:https://www.drugs.com/